Clostridium difficile

noreply@blogger.com (Jon Brassey) — Sat, 05 May 2007 20:07:00 +0000

This review is a pragmatic attempt to highlight recent research and some background reading on clostridium difficile. It should not be considered exhaustive, simply a way of reviewing some of the major developments and current thinking in the area.

Click here to see all the TRIP Evidence Reviews.

Evidence-Based Reports

Tolevamer Clostridium - difficile associated diarrhoea. National Horizon Scanning Centre, 2006
Clostridium difficile: findings and recommendations from a review of the epidemiology and a survey of directors of infection prevention and control in England. Health Protection Agency, 2006
Frequently asked questions about clostridium difficile. Health Protection Agency, 2007
Proton pump inhibitors and Clostridium difficile. Bandolier Extra, 2005

Clinical Guidelines

Clostridium difficile - Pathogen or pest? Canadian Paediatric Society, 2000
High impact intervention No. 6: reducing the risk of infection from and the presence of clostridium difficile. Department of Health, 2006

Systematic Reviews

The use of probiotics in the prevention and treatment of clostridium difficile diarrhea. Health Technology Assessment, 2005
Antibiotic treatment for Clostridium difficile-associated diarrhea in adults. Cochrane Database of Systematic Reviews, 2004
Antibiotics and hospital-acquired Clostridium difficile-associated diarrhoea: a systematic review. DARE, 2003

Recent articles in core journals

Evaluation of three rapid assays for detection of Clostridium difficile toxin A and toxin B in stool specimens. European Journal of Microbiology and Infectious Diseases, 2007
Narrative review: the new epidemic of Clostridium difficile-associated enteric disease. Annals of Internal Medicine, 2006
Use of gastric acid-suppressive agents and the risk of community-acquired Clostridium difficile-associated disease. JAMA. 2005
Proton pump inhibitor use and risk of community-acquired Clostridium difficile-associated disease defined by prescription for oral vancomycin therapy. Canadian Medical Association Journal, 2006
Emerging therapies in the treatment of Clostridium difficile-associated disease. Annals of Pharmacotherapy, 2006
Lack of value of repeat stool testing for Clostridium difficile toxin. American Journal of Medicine, 2006
A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. NEJM, 2005
An epidemic, toxin gene-variant strain of Clostridium difficile. NEJM, 2005

eTextbooks

Patient information

TRIP Evidence Reviews: C. difficile

Clostridium difficile